Kharitonov Sergei A
Section of Airway Disease, National Heart and Lung Institute, Imperial College and Royal Brompton and Harefield NHS Trust, London SW3 6LY, UK.
Vascul Pharmacol. 2005 Dec;43(6):371-8. doi: 10.1016/j.vph.2005.08.002. Epub 2005 Sep 28.
Nitric oxide (NO), a simple free radical gas, elicits a diverse range of physiological and pathophysiological effects, and plays an important role in pulmonary diseases. Nitrosative stress and nitration of proteins in airway epithelium maybe responsible for steroid resistance in asthma and their ineffectiveness in chronic obstructive pulmonary disease (COPD), supporting the potential role of future therapeutic strategies aimed at regulating NO synthesis in asthma and COPD. Here, we have reviewed the potential role of NO modulators (NO synthase inhibitors and NO donors), which if given on a regular basis may have clinical benefit in asthma and COPD.
一氧化氮（NO）是一种简单的自由基气体，可引发多种生理和病理生理效应，在肺部疾病中起重要作用。气道上皮中的亚硝化应激和蛋白质硝化可能是哮喘中类固醇抵抗及其在慢性阻塞性肺疾病（COPD）中无效的原因，这支持了未来旨在调节哮喘和COPD中NO合成的治疗策略的潜在作用。在此，我们综述了NO调节剂（NO合酶抑制剂和NO供体）的潜在作用，定期给予这些调节剂可能对哮喘和COPD具有临床益处。
