Goldacre Michael J, Kurina Lianne M, Wotton Clare J, Yeates David, Seagroat Valerie
Unit of Health-Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Old Road, Oxford OX3 7LF, UK.
Br J Psychiatry. 2005 Oct;187:334-8. doi: 10.1192/bjp.187.4.334.
For decades there has been interest in the possibility that people with schizophrenia might have some protection against cancer, and that, if this were so, it might hold clues about aetiological mechanisms in schizophrenia.
To study cancer incidence in schizophrenia.
Cohort analysis of linked hospital and death records was used to compare cancer rates in people with schizophrenia with a reference cohort.
We did not find a reduced risk for cancer overall (rate ratio 0.99,95% CI 0.90-1.08) or for most individual cancers. There was, however, a significantly low rate ratio for skin cancer (0.56,95% CI 0.36-0.83).
We found no evidence that schizophrenia confers protection against cancer in general. Low rates of cancer are consistent with the hypothesis that sun exposure may influence the development of schizophrenia, although other explanations are also possible.
数十年来，人们一直关注精神分裂症患者可能对癌症具有某种抵抗力这一可能性，并且如果真是如此，这可能为精神分裂症的病因机制提供线索。
研究精神分裂症患者的癌症发病率。
采用关联的医院和死亡记录进行队列分析，以比较精神分裂症患者与参照队列的癌症发生率。
我们未发现总体患癌风险降低（率比0.99，95%可信区间0.90 - 1.08），也未发现大多数个体癌症的风险降低。然而，皮肤癌的率比显著较低（0.56，95%可信区间0.36 - 0.83）。
我们没有发现证据表明精神分裂症总体上能预防癌症。癌症发生率低与阳光照射可能影响精神分裂症发病的假说相符，不过也可能有其他解释。
