精神分裂症患者及其亲属的面部识别记忆缺陷与视觉物体记忆表现
Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives.
作者信息
Calkins Monica E, Gur Ruben C, Ragland J Daniel, Gur Raquel E
机构信息
University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce St., Philadelphia, PA 19104, USA.
出版信息
Am J Psychiatry. 2005 Oct;162(10):1963-6. doi: 10.1176/appi.ajp.162.10.1963.
OBJECTIVE
Face recognition memory deficits in schizophrenia are attributed to frontotemporal dysfunction. Biological relatives of patients have similar deficits, suggesting genetic susceptibility. Because the impairment may reflect generalized object memory deficits, the authors evaluated both face and visual object recognition.
METHOD
The Penn Face Memory Test and Visual Object Learning Test were given to 102 patients with schizophrenia, 60 of their biological relatives, and 135 healthy comparison subjects.
RESULTS
Significant immediate and delayed face recognition deficits were observed in patients and their relatives. Although patients were more impaired in visual object memory than comparison subjects, relatives were not.
CONCLUSIONS
Face recognition deficits in patients with schizophrenia and their families are not secondary to generalized object memory deficits and may be an endophenotype reflecting frontotemporal impairment.
目的
精神分裂症患者的面部识别记忆缺陷归因于额颞叶功能障碍。患者的生物学亲属有类似缺陷，提示存在遗传易感性。由于这种损害可能反映出一般性的物体记忆缺陷，作者对面部和视觉物体识别进行了评估。
方法
对102例精神分裂症患者、其中60例患者的生物学亲属以及135名健康对照者进行了宾夕法尼亚面部记忆测试和视觉物体学习测试。
结果
在患者及其亲属中观察到显著的即时和延迟面部识别缺陷。虽然患者在视觉物体记忆方面比对照者受损更严重，但亲属并非如此。
结论
精神分裂症患者及其家属的面部识别缺陷并非继发于一般性物体记忆缺陷，可能是反映额颞叶损害的一种内表型。
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