Cademartiri Filippo, Runza Giuseppe, Mollet Nico R, Luccichenti Giacomo, Belgrano Manuel, Somers Pamela, Knaapen Michiel, Verheye Stefan, Bruining Nico, Hamers Ronald, Midiri Massimo, De Feyter Pim J, Krestin Gabriel P
Dipartimento di Radiologia, Erasmus Medical Cencter, Rotterdam, The Netherlands.
Radiol Med. 2005 Sep;110(3):234-40.
To assess the variability in attenuation of coronary plaques with multislice CT-angiography (MSCT-CA) in an ex-vivo model with varying convolution kernels.
MSCT-CA (Sensation 16, Siemens) was performed in three ex-vivo left coronary arteries after instillation of contrast material solution (Iomeprol 400 mgI/ml, dilution: 1/80). The specimens were placed in oil to simulate epicardial fat. Scan parameters: slices 16/0.75 mm, rotation time 375 ms, feed/rotation 3.0 mm, mAs 500, slice thickness 1 mm, and FOV 50 mm. Datasets were reconstructed using 4 different kernels (B30f-smooth, B36f-medium smooth, B46f-medium, and B60f-sharp). Each scan was scored for the presence of plaques. Once a plaque was detected, the operator performed attenuation measurements (HU) in coronary lumen, oil, calcified and soft plaque tissue using the same settings in all datasets. The results were compared with T-test and correlated with Pearson's test.
Overall, 464 measurements were performed. Significant differences (p<0.05) were found for the mean attenuation of lumen (B30f/B36f, B30f/B60f, B36f/B46f, B36f/B60f, and B46f/B60f), oil (B30f/B36f, B30f/B46f, B30f/B60f, B36f/B46f, and B46f/B60f), calcium (all kernels), and plaque (B30f/B36f, B30f/B46f, B30f/B60f, and B46f/B60f) using 4 different kernels. The attenuation values (mean+/-SD) within the lumen (246+/-6, 215+/-13, 248+/-5, and 270+/-7), oil (-123+/-3, -127+/-1, -121+/-6, and -127+/-4), calcified plaque tissue (703+/-334, 739+/-364, 817+/-381, and 1181+/-503), and soft plaque tissue (134+/-56, 111+/-49, 120+/-56, and 102+/-41) showed high correlation (p<0.001) when attenuation of all structures were compared in different kernels.
Use of sharper convolution kernels significantly increases the attenuation of the calcium within coronary plaques and reduces the attenuation of soft plaque tissue.
在一个使用不同卷积核的离体模型中，评估多层螺旋CT血管造影（MSCT-CA）对冠状动脉斑块衰减的变异性。
在3条离体左冠状动脉内注入造影剂溶液（碘美普尔400mgI/ml，稀释比例：1/80）后，使用MSCT-CA（西门子Sensation 16）进行扫描。将标本置于油中以模拟心外膜脂肪。扫描参数：层厚16×0.75mm，旋转时间375ms，进床/旋转3.0mm，管电流500mAs，层厚1mm，视野50mm。使用4种不同的卷积核（B30f-平滑、B36f-中等平滑、B46f-中等、B60f-锐利）重建数据集。对每次扫描的斑块存在情况进行评分。一旦检测到斑块，操作人员在所有数据集中使用相同设置对冠状动脉腔、油、钙化斑块组织和软斑块组织进行衰减测量（HU）。结果采用t检验进行比较，并与Pearson检验进行相关性分析。
总体上共进行了464次测量。在使用4种不同卷积核对管腔（B30f/B36f、B30f/B60f、B36f/B46f、B36f/B60f和B46f/B60f）、油（B30f/B36f、B30f/B46f、B30f/B60f、B36f/B46f和B46f/B60f）、钙化（所有卷积核）和斑块（B30f/B36f、B30f/B46f、B30f/B60f和B46f/B60f）的平均衰减进行比较时，发现存在显著差异（p<0.05）。当比较不同卷积核中所有结构的衰减时，管腔内（246±6、215±13、248±5和270±7）、油内（-123±3、-127±1、-121±6和-127±4）、钙化斑块组织内（703±334、739±364、817±381和1181±503）以及软斑块组织内（134±56、111±49、120±56和102±41）的衰减值显示出高度相关性（p<0.001）。
使用更锐利的卷积核可显著增加冠状动脉斑块内钙化的衰减，并降低软斑块组织的衰减。
