Corhay J L, Louis R
Service de pneumologie, CHU Sart Tilman B35, 4000 Liège I, Belgique.
Rev Med Suisse. 2005 Aug 24;1(30):1967-9, 1971-2.
Tiotropium is a long-acting anticholinergic bronchodilator, inhaled only once a day, which produces relaxation of airway smooth muscle through antagonism of acetylcholine at M3-muscarinic receptors. Its duration of action is at least 24 h with once daily administration of tiotropium. Several studies have shown its efficacy and its good tolerance in the treatment of patients who are suffering from moderate to very severe chronic obstructive pulmonary disease (COPD). Tiotropium improves spirometric measurements and quality of life, and reduces dyspnea and exacerbation rate in COPD patients.
噻托溴铵是一种长效抗胆碱能支气管扩张剂，每天只需吸入一次，通过拮抗M3型毒蕈碱受体上的乙酰胆碱来松弛气道平滑肌。每日服用一次噻托溴铵，其作用持续时间至少为24小时。多项研究表明，它在治疗中度至重度慢性阻塞性肺疾病（COPD）患者方面具有疗效且耐受性良好。噻托溴铵可改善肺功能测量指标和生活质量，并降低COPD患者的呼吸困难和急性加重率。
