Zhou G, Chen G, Cui S, Sun J, Yang D
Department of Radiotherapy, General Hospital, People's Liberation Army, Bejiing 100853, China.
Zhonghua Wai Ke Za Zhi. 2001 Dec;39(12):925-7.
To study the long-term treatment results and acute irradiation response as well as complications following external irradiation combined with intracavitary brachytherapy.
After loading intracavitary brachytherapy was used for patients with esophageal cancer. In 92 patients with esophageal cancer, 47 (group A) were treated with external irradiation only, and 45 (group B) with external irradiation and brachytherapy. The doses were 60.0 Gy - 70.0 Gy per 6-7 week for external irradiation, using 8 or 10 MV liner accelerator, and 5.0-8.0 Gy per fraction for intracavitary therapy.
There was a significant difference in acute response and complications as well as local recurrence rate between the two groups (P < 0.05). The survival rates of groups A and B at 1,3 and 5 years were 59.6%, 25.6%, 10.6% and 80.0%, 46.7%, 26.7% respectively (P < 0.05 respectively, using chi2 test). The complications related to intracavitary irradiation were esophageal perforation, esophagorrhagia, esophagotracheal fistula and esophageal narrowing. 66 patients died and 9 lost follow-up, giving a follow up rate of 90.2%.
External irradiation combined with afterloading intracavitary brachytherapy for esophageal cancer can reduce the local recurrence and enhance the long-term survival but with an increase of complications compared with the patients treated with external irradiation alone.
研究外照射联合腔内近距离放疗的长期治疗效果、急性放射反应及并发症。
食管癌患者采用腔内近距离放疗后装治疗。92例食管癌患者中，47例（A组）仅接受外照射治疗，45例（B组）接受外照射及近距离放疗。外照射采用8或10MV直线加速器，每6 - 7周给予60.0Gy - 70.0Gy剂量，腔内治疗每次给予5.0 - 8.0Gy剂量。
两组在急性反应、并发症及局部复发率方面存在显著差异（P < 0.05）。A组和B组1年、3年和5年生存率分别为59.6%、25.6%、10.6%和80.0%、46.7%、26.7%（分别采用卡方检验，P均< 0.05）。与腔内照射相关的并发症有食管穿孔、食管出血、食管气管瘘和食管狭窄。66例患者死亡，9例失访，随访率为90.2%。
与单纯外照射治疗的患者相比，食管癌外照射联合后装腔内近距离放疗可降低局部复发率，提高长期生存率，但并发症有所增加。
