Will Cindy L, Lührmann Reinhard
Max Planck Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, D-37077 Göttingen, Germany.
Biol Chem. 2005 Aug;386(8):713-24. doi: 10.1515/BC.2005.084.
Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.
前体信使核糖核酸（pre-mRNA）剪接由两种独特的剪接体催化，分别称为U2依赖型或U12依赖型。与特征明确的U2依赖型剪接体不同，关于含量较少的U12型剪接体仍有许多有待了解之处。本综述聚焦于阐明次要的U12依赖型剪接体的结构与功能方面的最新进展。同时也突出了U12依赖型和U2依赖型剪接体之间有趣的异同点。
