Semchuk K M, Love E J, Lee R G
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, AB, Canada.
Neurology. 1992 Jul;42(7):1328-35. doi: 10.1212/wnl.42.7.1328.
This population-based case-control study of 130 Calgary residents with neurologist-confirmed idiopathic Parkinson's disease (PD) and 260 randomly selected age- and sex-matched community controls attempted to determine whether agricultural work or the occupational use of pesticide chemicals is associated with an increased risk for PD. We obtained by personal interviews lifetime occupational histories, including chemical exposure data, and analyzed the data using conditional logistic regression for matched sets. In the univariate analysis, a history of field crop farming, grain farming, herbicide use, or insecticide use resulted in a significantly increased crude estimate of the PD risk, and the data suggested a dose-response relation between the PD risk and the cumulative lifetime exposure to field crop farming and to grain farming. However, in the multivariate analysis, which controlled for potential confounding or interaction between the exposure variables, previous occupational herbicide use was consistently the only significant predictor of PD risk. These results support the hypothesis that the occupational use of herbicides is associated with an increased risk for PD.
这项基于人群的病例对照研究，纳入了130名经神经科医生确诊为特发性帕金森病（PD）的卡尔加里居民以及260名随机选取的年龄和性别匹配的社区对照者，旨在确定从事农业工作或职业性使用农药化学品是否与PD风险增加相关。我们通过个人访谈获取了终生职业史，包括化学物质暴露数据，并使用条件逻辑回归对匹配组数据进行分析。在单变量分析中，大田作物种植、谷物种植、使用除草剂或杀虫剂的历史导致PD风险的粗略估计值显著增加，并且数据表明PD风险与终生累计大田作物种植和谷物种植暴露之间存在剂量反应关系。然而，在多变量分析中，该分析控制了暴露变量之间的潜在混杂或相互作用，既往职业性使用除草剂始终是PD风险的唯一显著预测因素。这些结果支持以下假设：职业性使用除草剂与PD风险增加相关。
