Tüchsen F, Jensen A A
Department of Epidemiology and Surveillance, National Institute of Occupational Health, Copenhagen, Denmark.
Scand J Work Environ Health. 2000 Aug;26(4):359-62. doi: 10.5271/sjweh.554.
This study examined the possible association between agricultural and horticultural work and the subsequent morbidity of Parkinson's disease.
Fixed cohorts of 2,273,872 men and women aged 20-59 years on 1 January 1981 and identified in the Central Population Register of Denmark were followed, and all first-time hospitalizations with Parkinson's disease as the principal diagnosis during the 13 years until 31 December 1993 were recorded. Standardized hospitalization ratios (SHR) were calculated using all gainfully employed persons as the standard and by multiplying the ratio by 100. Ninety-five percent confidence intervals (95% CI) were calculated on the assumption of a Poisson distribution.
A high risk of Parkinson's disease was found for the men and women in agriculture and horticulture (134 cases, SHR 132, 95% CI 111-156). Statistically significantly high risks were found for farmers (79 cases, SHR 130, 95% CI 103-163) and for all men in agriculture and horticulture (109 cases, SHR 134, 95% CI 109-162).
A consistent pattern of high Parkinson's disease morbidity was found among occupational groups employed in agriculture and horticulture.
本研究探讨了农业和园艺工作与帕金森病后续发病之间可能存在的关联。
对1981年1月1日年龄在20 - 59岁、在丹麦中央人口登记册中登记的2273872名男性和女性固定队列进行随访，并记录了截至1993年12月31日的13年期间所有以帕金森病作为主要诊断的首次住院情况。以所有有酬就业人员为标准计算标准化住院率（SHR），并将该比率乘以100。在泊松分布假设的基础上计算95%置信区间（95%CI）。
发现从事农业和园艺工作的男性和女性患帕金森病的风险较高（134例，SHR 132，95%CI 111 - 156）。发现农民（79例，SHR 130，95%CI 103 - 163）以及所有从事农业和园艺工作的男性（109例，SHR 134，95%CI 109 - 162）的风险在统计学上显著较高。
在从事农业和园艺工作的职业群体中发现了帕金森病高发病率的一致模式。
