Frost Marlene H, Slezak Jeffrey M, Tran Nho V, Williams Constance I, Johnson Joanne L, Woods John E, Petty Paul M, Donohue John H, Grant Clive S, Sloan Jeff A, Sellers Thomas A, Hartmann Lynn C
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.
J Clin Oncol. 2005 Nov 1;23(31):7849-56. doi: 10.1200/JCO.2005.09.233. Epub 2005 Oct 3.
Contralateral prophylactic mastectomy (CPM) is one option for reducing the risk of a second breast cancer in women with a personal and family history of breast cancer. Few data are available regarding satisfaction, psychological, and social function after CPM. The purpose of this research is to evaluate women's long-term satisfaction with CPM, factors influencing satisfaction, and psychological and social function after CPM.
This was a descriptive study of all women with a family history of breast cancer, known to be alive, who elected CPM at Mayo Clinic (Rochester, MN) between 1960 and 1993 (n = 621). Ninety-four percent of the women (n = 583) completed a study-specific questionnaire.
A mean of 10.3 years after the procedure, the majority of women (83%) were satisfied with their CPM. A smaller number were neutral (8%) or dissatisfied (9%). Women who had a subcutaneous mastectomy had more problems with reconstruction, and fewer of these women were satisfied than women with simple mastectomy. Decreased satisfaction with CPM was associated with decreased satisfaction with appearance, complications with reconstruction, reconstruction after CPM, and increased level of stress in life. The majority of women experienced no change or favorable effects in self-esteem (83%), level of stress in life (83%), and emotional stability (88%). Satisfaction with body appearance, feelings of femininity, and sexual relationships were the most adversely affected with 33%, 26%, and 23% of the women responding negatively.
Although most women are satisfied with CPM, each woman should weigh the benefits alongside the potential adverse effects.
对侧预防性乳房切除术(CPM)是降低有乳腺癌个人和家族史女性患对侧乳腺癌风险的一种选择。关于CPM术后的满意度、心理和社会功能的数据较少。本研究的目的是评估女性对CPM的长期满意度、影响满意度的因素以及CPM后的心理和社会功能。
这是一项对所有有乳腺癌家族史且已知在世的女性进行的描述性研究,这些女性于1960年至1993年期间在梅奥诊所(明尼苏达州罗切斯特)选择了CPM(n = 621)。94%的女性(n = 583)完成了一份针对该研究的问卷。
术后平均10.3年,大多数女性(83%)对其CPM感到满意。少数女性持中立态度(8%)或不满意(9%)。接受皮下乳房切除术的女性在重建方面问题更多,与接受单纯乳房切除术的女性相比,这些女性中满意的人数更少。对CPM满意度的降低与对外表满意度降低、重建并发症、CPM后的重建以及生活压力水平增加有关。大多数女性在自尊(83%)、生活压力水平(83%)和情绪稳定性(88%)方面没有变化或有积极影响。对身体外观、女性气质和性关系的满意度受到的负面影响最大,分别有33%、26%和23%的女性给出负面反馈。
尽管大多数女性对CPM感到满意,但每位女性都应权衡其益处与潜在的不良影响。