Tanghe An, Carbrey Jennifer M, Agre Peter, Thevelein Johan M, Van Dijck Patrick
Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium.
Appl Environ Microbiol. 2005 Oct;71(10):6434-7. doi: 10.1128/AEM.71.10.6434-6437.2005.
Aquaporins are members of the major intrinsic protein superfamily of integral membrane proteins which enable the transport of water, glycerol, and other solutes across membranes in various organisms. In microorganisms, the physiological role of aquaporins is not yet defined. We found a clear correlation between expression of the Candida albicans aquaporin-encoding gene AQY1 and freeze tolerance. A connection with the function for the aquaporin in the natural environment of C. albicans is, however, not obvious.
水通道蛋白是整合膜蛋白中主要内在蛋白超家族的成员，它能够使水、甘油和其他溶质在各种生物体中跨膜运输。在微生物中，水通道蛋白的生理作用尚未明确。我们发现白色念珠菌水通道蛋白编码基因AQY1的表达与耐冻性之间存在明显的相关性。然而，水通道蛋白在白色念珠菌自然环境中的功能联系并不明显。
