Boyd J, Buick J, Cosgrove J A, Stansell P
Biophysical and Biomedical Research Group, School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, NSW, 2351, Australia.
Phys Med Biol. 2005 Oct 21;50(20):4783-96. doi: 10.1088/0031-9155/50/20/003. Epub 2005 Sep 27.
The lattice Boltzmann model is used to observe changes in the velocity flow and shear stress in a carotid artery model during a simulated stenosis growth. Near wall shear stress in the unstenosed artery is found to agree with literature values. The model also shows regions of low velocity, rotational flow and low near wall shear stress along parts of the walls of the carotid artery that have been identified as being prone to atherosclerosis. These regions persist during the simulated stenosis growth, suggesting that atherosclerotic plaque build-up creates regions of flow with properties that favour atherosclerotic progression.
格子玻尔兹曼模型用于观察模拟狭窄生长过程中颈动脉模型内的流速和剪应力变化。发现未狭窄动脉中的近壁剪应力与文献值相符。该模型还显示,在已确定易患动脉粥样硬化的颈动脉壁部分,存在低速、旋转流和近壁剪应力较低的区域。这些区域在模拟狭窄生长过程中持续存在,表明动脉粥样硬化斑块的形成会产生具有促进动脉粥样硬化进展特性的血流区域。