Marshall Ian, Zhao Shunzhi, Papathanasopoulou Panorea, Hoskins Peter, Xu Yun
Department of Medical and Radiological Sciences, Medical Physics, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
J Biomech. 2004 May;37(5):679-87. doi: 10.1016/j.jbiomech.2003.09.032.
Pulsatile flow was studied in physiologically realistic models of a normal and a moderately stenosed (30% diameter reduction) human carotid bifurcation. Time-resolved velocity measurements were made using magnetic resonance imaging, from which wall shear stress (WSS) vectors were calculated. Velocity measurements in the inflow and outflow regions were also used as boundary conditions for a computational fluid dynamics (CFD) model. Experimental flow patterns and derived WSS vectors were compared qualitatively with the corresponding CFD predictions. In the stenosed phantom, flow in the bulb region of the "internal carotid artery" was concentrated along the outer wall, with a region of low and recirculating flow near the inner wall. In the normal phantom, the converse was found, with a low flow region near the outer wall of the bulb. Time-averaged WSS and oscillatory shear index were also markedly different for the two phantoms.
在正常和中度狭窄（直径减少30%）的人体颈动脉分叉的生理逼真模型中研究了脉动流。使用磁共振成像进行时间分辨速度测量，并据此计算壁面剪应力（WSS）向量。流入和流出区域的速度测量结果也用作计算流体动力学（CFD）模型的边界条件。将实验流动模式和导出的WSS向量与相应的CFD预测进行了定性比较。在狭窄模型中，“颈内动脉”球部区域的血流集中在外壁，在内壁附近有一个低血流和回流区域。在正常模型中，情况相反，球部外壁附近有一个低血流区域。两种模型的时间平均WSS和振荡剪切指数也有显著差异。
