Barron Susan, White Aaron, Swartzwelder H Scott, Bell Richard L, Rodd Zachary A, Slawecki Craig J, Ehlers Cindy L, Levin Edward D, Rezvani Amir H, Spear Linda P
Psychology Department, University of Kentucky, Lexington, KY 40506-0044, USA.
Alcohol Clin Exp Res. 2005 Sep;29(9):1720-5. doi: 10.1097/01.alc.0000179220.79356.e5.
This article presents an overview of the proceedings from a symposium entitled "Is adolescence special? Possible age-related vulnerabilities to chronic alcohol or nicotine exposure," organized by Susan Barron and Linda Spear and held at the 2004 Research Society on Alcoholism Meeting in Vancouver, British Columbia. This symposium, co-sponsored by the Fetal Alcohol Syndrome Study Group and the Neurobehavioral Teratology Society, focused on our current knowledge regarding the long-term consequences of ethanol and/or nicotine exposure during adolescence with the emphasis on data from rodent models. The support from these two societies represents the understanding by these research groups that adolescence represents a unique developmental stage for the effects of chronic drug exposure and also marks an age in which many risky behaviors including alcohol consumption and smoking typically begin. The speakers included (1) Aaron White, who presented data on the effects of adolescent ethanol exposure on subsequent motor or cognitive response to an ethanol challenge in adulthood; (2) Richard Bell, who presented data suggesting that genetic differences could play a role in adolescent vulnerability to ethanol; (3) Craig Slawecki, who presented data looking at the effects of chronic exposure to alcohol or nicotine on neurophysiologic and behavioral end points; and (4) Ed Levin, who presented data on acute and long-term consequences of adolescent nicotine exposure. Finally, Linda Spear provided some summary points and recommendations regarding unresolved issues and future directions.
本文概述了一场题为“青春期特殊吗？与年龄相关的慢性酒精或尼古丁暴露潜在易感性”的研讨会的会议记录。该研讨会由苏珊·巴伦和琳达·斯皮尔组织，于2004年在不列颠哥伦比亚省温哥华举行的酒精研究学会会议上召开。本次研讨会由胎儿酒精综合征研究小组和神经行为致畸学学会共同赞助，重点关注我们目前关于青春期乙醇和/或尼古丁暴露长期后果的知识，重点是来自啮齿动物模型的数据。这两个学会的支持表明，这些研究小组认识到青春期是慢性药物暴露影响的一个独特发育阶段，也是许多危险行为（包括饮酒和吸烟）通常开始的年龄。发言者包括：（1）亚伦·怀特，他展示了青春期乙醇暴露对成年后乙醇激发试验后续运动或认知反应影响的数据；（2）理查德·贝尔，他展示的数据表明基因差异可能在青春期对乙醇的易感性中起作用；（3）克雷格·斯拉韦茨基，他展示了长期暴露于酒精或尼古丁对神经生理和行为终点影响的数据；（4）埃德·莱文，他展示了青春期尼古丁暴露的急性和长期后果的数据。最后，琳达·斯皮尔就未解决的问题和未来方向提供了一些总结要点和建议。
