Sporn Michael B, Liby Karen T
Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA.
Nat Clin Pract Oncol. 2005 Oct;2(10):518-25. doi: 10.1038/ncponc0319.
We review fundamental processes, such as mutation, oxidative stress, and inflammation that are critical for carcinogenesis and provide specific molecular targets for new chemopreventive agents. New information from molecular biology studies has identified such targets, including regulatory molecules such as Nrf2 (nuclear factor erythroid 2-related factor 2), epidermal growth factor receptor kinases, phosphatidylinositol 3-kinase, components of the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway, nuclear factor-kappaB, and cyclin D. The development of new drugs for the control of these targets that are both safe and effective will be important for the future of cancer chemoprevention.
我们回顾了对致癌作用至关重要的基本过程，如突变、氧化应激和炎症，并为新型化学预防剂提供了特定的分子靶点。分子生物学研究的新信息已确定了此类靶点，包括诸如Nrf2（核因子红细胞2相关因子2）、表皮生长因子受体激酶、磷脂酰肌醇3激酶、Janus激酶-信号转导子和转录激活子（JAK-STAT）通路的组成部分、核因子-κB和细胞周期蛋白D等调节分子。开发既能安全又有效地控制这些靶点的新药，对癌症化学预防的未来至关重要。
