Cuttner Janet, Spiera Harry, Troy Kevin, Wallenstein Sylvan
Department of Medicine, Mount Sinai Medical Center, 1735 York Avenue, New York, NY 10128, USA.
J Rheumatol. 2005 Oct;32(10):1884-7.
To investigate the relationship of prior autoimmune disease to the development of non-Hodgkin's lymphoma (NHL).
Patients with NHL (n = 278) seen from 1993 to 2002 were compared with a group of patients with other hematological disorders (controls, n = 317) seen at the same time. All patients were questioned about prior autoimmune disease. Comparisons between NHL patients and controls were based on analysis of a 2 2 table of counts using Fisher's exact test. Analysis of the effect of autoimmune disease on NHL status, controlling for other risk factors, was performed using logistic regression.
Thirty-six (13%) NHL patients had a prior autoimmune disease compared to 5% of controls (p = 0.001). Sixty-nine percent of NHL patients with a prior autoimmune disease were female compared to 43% without a prior autoimmune disease, and this was similar in control patients, 69% and 48%, respectively. Twenty percent of all women with NHL had a history of autoimmune disease compared to 7% of women in the control group (p = 0.001). Nineteen of the NHL patients with autoimmune disease (56%) received immunosuppressive treatment compared to 5 (38%) in the controls.
Autoimmune disease may account in part for the increase in NHL, especially in women.
研究既往自身免疫性疾病与非霍奇金淋巴瘤（NHL）发生之间的关系。
将1993年至2002年期间诊治的278例NHL患者与同期诊治的317例其他血液系统疾病患者（对照组）进行比较。所有患者均被询问既往自身免疫性疾病情况。NHL患者与对照组之间的比较基于使用Fisher精确检验对计数的2×2列联表进行分析。使用逻辑回归分析自身免疫性疾病对NHL状态的影响，并对其他危险因素进行控制。
36例（13%）NHL患者有既往自身免疫性疾病，而对照组为5%（p = 0.001）。有既往自身免疫性疾病的NHL患者中69%为女性，无既往自身免疫性疾病的患者中这一比例为43%，对照组患者中这两个比例分别为69%和48%，情况相似。所有患NHL的女性中20%有自身免疫性疾病病史，而对照组女性中这一比例为7%（p = 0.001）。19例有自身免疫性疾病的NHL患者（56%）接受了免疫抑制治疗，而对照组为5例（38%）。
自身免疫性疾病可能在一定程度上导致了NHL发病率的增加，尤其是在女性中。
