胆囊收缩素拮抗剂对胆囊收缩素诱导的小鼠运动活动抑制的影响。

Effects of CCK antagonists on CCK-induced suppression of locomotor activity in mice.

作者信息

Hirosue Y, Inui A, Miura M, Nakajima M, Okita M, Himori N, Baba S, Kasuga M

机构信息

Second Department of Internal Medicine, Kobe University School of Medicine, Chuo-ku, Japan.

出版信息

Peptides. 1992 Jan-Feb;13(1):155-7. doi: 10.1016/0196-9781(92)90156-w.

DOI:10.1016/0196-9781(92)90156-w

PMID:1620653

Abstract

Sulfated cholecystokinin octapeptide (CCK-8) was administered either intraperitoneally or into the cerebral ventricle of fully conscious mice, and locomotor activity was quantified. CCK-8 administered by either route suppressed locomotor activity. Subcutaneously administered selective CCK-A receptor antagonist, L-364,718 (1 mg/kg), reversed the inhibitory effect of centrally as well as peripherally administered CCK-8, but the selective CCK-B receptor antagonist, L-365,260 (1 mg/kg), did not. These results demonstrate that centrally as well as peripherally administered CCK-8 suppresses locomotor activity in mice through an interaction with CCK-A, but not CCK-B, receptors.

摘要

将硫酸化胆囊收缩素八肽（CCK - 8）腹腔注射或注入完全清醒小鼠的脑室，并对运动活性进行定量。通过这两种途径给药的CCK - 8均抑制运动活性。皮下注射选择性CCK - A受体拮抗剂L - 364,718（1毫克/千克）可逆转中枢和外周给药CCK - 8的抑制作用，但选择性CCK - B受体拮抗剂L - 365,260（1毫克/千克）则不能。这些结果表明，中枢和外周给药的CCK - 8通过与CCK - A而非CCK - B受体相互作用来抑制小鼠的运动活性。