Steemers Frank J, Gunderson Kevin L
Illumina Inc., 9885 Towne Centre Drive, San Diego, CA 92121, USA.
Pharmacogenomics. 2005 Oct;6(7):777-82. doi: 10.2217/14622416.6.7.777.
Illumina, Inc., based in San Diego (CA, USA), is a genomics tool company that develops and markets integrated array-based systems and assays for a broad range of applications including genotyping, gene expression and epigenetics. Product offerings range from focused assay sets (up to 1,536 multiplexed assays) to whole-genome analysis (>100,000 assays/sample). Illumina's two microarray platforms, the Sentrix Array Matrix and the Sentrix BeadChip, are characterized by small (3 microm) feature size, dense feature packing (over 10 million features can be deployed on a single microarray) and the ability to analyze, in parallel, multiple samples on the same device. Illumina has developed a spectrum of proprietary assays (GoldenGate, Infinium, and DASL) for application on our microarray platform. These assays have been successfully employed for a number of applications, including collection of the majority of the Phase I genotyping data for the International HapMap Project. Illumina are focusing our activities on extending the applications of the above assays and developing new assays for future products. Illumina's goal is to deliver high-performance, high-throughput solutions that enable researchers to expand experimental scale while reducing the cost of large-scale research.
位于美国加利福尼亚州圣地亚哥的Illumina公司是一家基因组学工具公司,该公司开发并销售基于芯片的集成系统和检测方法,用于包括基因分型、基因表达和表观遗传学等广泛的应用领域。其产品范围从聚焦检测集(多达1536个多重检测)到全基因组分析(>100,000个检测/样本)。Illumina的两个微阵列平台,即Sentrix Array Matrix和Sentrix BeadChip,具有小(3微米)特征尺寸、密集特征排列(单个微阵列上可部署超过1000万个特征)以及能够在同一设备上并行分析多个样本的特点。Illumina已开发出一系列专有的检测方法(GoldenGate、Infinium和DASL)用于其微阵列平台。这些检测方法已成功应用于许多领域,包括为国际人类基因组单体型图计划收集大部分一期基因分型数据。Illumina正致力于扩展上述检测方法的应用,并为未来产品开发新的检测方法。Illumina的目标是提供高性能、高通量的解决方案,使研究人员能够扩大实验规模,同时降低大规模研究的成本。