钙通道阻滞剂对大鼠福尔马林诱导的伤害感受和炎症的影响。
Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats.
作者信息
Gürdal H, Sara Y, Tulunay F C
机构信息
Department of Pharmacology, Medical School of Ankara University, Turkey.
出版信息
Pharmacology. 1992;44(5):290-6. doi: 10.1159/000138932.
The possible anti-inflammatory and antinociceptive effects of nitrendipine, nicardipine, diltiazem and verapamil were examined with formalin test in the rat paw. Pretreatment with these calcium channel blockers 1 h before formalin injection diminished formalin-induced inflammatory changes and nociceptive responses. Formalin-induced nociceptive responses were inhibited 20-90% by the calcium channel blockers. Nitrendipine and nicardipine were found to be highly effective in inhibiting the inflammatory changes, whereas the effects of verapamil and diltiazem were partial. Administration of naloxone affected neither the inflammatory changes and nociceptive responses induced by formalin nor the antiinflammatory and antinociceptive effects of the calcium channel blockers. The results suggest the possible anti-inflammatory and naloxone-insensitive antinociceptive properties of calcium channel blockers.
在大鼠爪部通过福尔马林试验研究了尼群地平、尼卡地平、地尔硫䓬和维拉帕米可能的抗炎和镇痛作用。在注射福尔马林前1小时用这些钙通道阻滞剂进行预处理，可减轻福尔马林诱导的炎症变化和伤害性反应。钙通道阻滞剂可抑制20%-90%的福尔马林诱导的伤害性反应。发现尼群地平和尼卡地平在抑制炎症变化方面非常有效，而维拉帕米和地尔硫䓬的作用是部分性的。给予纳洛酮既不影响福尔马林诱导的炎症变化和伤害性反应，也不影响钙通道阻滞剂的抗炎和镇痛作用。结果提示钙通道阻滞剂可能具有抗炎和对纳洛酮不敏感的镇痛特性。
Zotero 插件