肝肺综合征

Hepatopulmonary syndrome.

作者信息

Arguedas Miguel R, Fallon Michael B

机构信息

Department of Medicine, Division of Gastroenterology/Hepatology, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294, USA.

出版信息

Clin Liver Dis. 2005 Nov;9(4):733-46, viii. doi: 10.1016/j.cld.2005.07.006.

DOI:10.1016/j.cld.2005.07.006

PMID:16207573

Abstract

The hepatopulmonary syndrome is an increasingly important vascular complication of cirrhosis where microvascular dilatation impairs arterial oxygenation in the setting of liver disease. This syndrome is identified in as many as 20% of patients evaluated for liver transplantation and results in increased mortality. No clearly effective medical therapies are available, and liver transplantation is the only established treatment. Pathophysiologic insights obtained from experimental models may lead to the development of novel and effective medical treatments.

摘要

肝肺综合征是肝硬化日益重要的血管并发症，在肝病背景下，微血管扩张会损害动脉氧合。在接受肝移植评估的患者中，多达20%的患者被诊断出患有该综合征，这会导致死亡率增加。目前尚无明确有效的药物治疗方法，肝移植是唯一已确立的治疗手段。从实验模型中获得的病理生理学见解可能会促成新型有效药物治疗方法的开发。