[大剂量5α-还原酶抑制剂对雄性大鼠精子发生的影响]
[Effect of large-dosage of 5alpha-reductase inhibitors on the spermatogenesis of male rats].
作者信息
Wang Xiao-dong, Jia Yue, Cui Yu-gui, Wang Xing-hai, Tong Jian-sun, Ma Ding-zhi, Cai Rui-fen, Di Fu-song
机构信息
Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
出版信息
Zhonghua Nan Ke Xue. 2005 Sep;11(9):652-4.
OBJECTIVE
To identify the role of 5alpha-reductase in the spermatogenesis of male rats by studying the effect of two 5alpha-reductase inhibitors, Epristeride and Finasteride, on the spermatogenesis in male Sprague-Dawley (SD) rats.
METHODS
Changes in the weight of the testis, serum testosterone and dihydrotestosterone levels, epididymal sperm count, and reproductive function were observed and analyzed after the two 5alpha-reductase inhibitors were administered to male SD rats orally.
RESULTS
The experiment showed that in comparison with control animals, both the two 5alpha-reductase inhibitors: 1. suppressed the development of the prostate and reduced the weight of the testis in the experimental groups (P < 0.05); 2. decreased the serum level of dihydrotestosterone and enhanced testosterone; 3. inhibited epididymal sperm count and productive function.
CONCLUSION
High dosages of the 5alpha-reductase inhibitor, Epristeride, can suppress the development of the prostate and reduce the weight of the testis, decrease dihydrotestosterone, and inhibit spermatogenesis and productive function in male rats.
目的
通过研究两种5α-还原酶抑制剂依立雄胺和非那雄胺对雄性斯普拉格-道利（SD）大鼠精子发生的影响，确定5α-还原酶在雄性大鼠精子发生中的作用。
方法
对雄性SD大鼠口服两种5α-还原酶抑制剂后，观察并分析睾丸重量、血清睾酮和双氢睾酮水平、附睾精子计数及生殖功能的变化。
结果
实验表明，与对照动物相比，两种5α-还原酶抑制剂均：1. 抑制了实验组前列腺的发育并减轻了睾丸重量（P < 0.05）；2. 降低了血清双氢睾酮水平并提高了睾酮水平；3. 抑制了附睾精子计数和生殖功能。
结论
高剂量的5α-还原酶抑制剂依立雄胺可抑制雄性大鼠前列腺的发育，减轻睾丸重量，降低双氢睾酮水平，并抑制精子发生和生殖功能。
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