Obuchowski Michał
Medical University of Gdansk, Intercollegiate Faculty of Biotechnology UG-AMG, Department of Cell Biology, 1 Debinki St., 80-811 Gdansk, Poland.
Postepy Biochem. 2005;51(1):95-104.
Gram-positive soil bacterium Bacillus subtilis possesses six eukaryotic-like serine-threonine protein phosphatases. These enzymes play an important role in the cell. The response to environmental or nutrional stress conditions are controlled by three Rsb phosphatases: RsbX, RsbU and RsbP. Phosphatases are also involved in endospore formation process (SpoIIE) and sugar transport (kinase/phosphatase Hpr). Moreover in the cell there are phosphatases with still unknown function (PrpC and PrpE). Cellular processes, presented here are regulated by serine/threonine protein phosphatases and very important for bacterial survival in natural environment. Protein phosphatases must act in cooperation with protein kinases and deserve the same attention as kinases.
革兰氏阳性土壤细菌枯草芽孢杆菌拥有六种真核生物样丝氨酸 - 苏氨酸蛋白磷酸酶。这些酶在细胞中发挥着重要作用。对环境或营养应激条件的反应由三种Rsb磷酸酶控制:RsbX、RsbU和RsbP。磷酸酶还参与芽孢形成过程(SpoIIE)和糖转运(激酶/磷酸酶Hpr)。此外,细胞中还有功能尚不清楚的磷酸酶(PrpC和PrpE)。这里介绍的细胞过程受丝氨酸/苏氨酸蛋白磷酸酶调节,对细菌在自然环境中的生存非常重要。蛋白磷酸酶必须与蛋白激酶协同作用,应得到与激酶同等的关注。