Itsenko Oleksiy, Långström Bengt
Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Box 599, S-751 21 Uppsala, Sweden.
Org Lett. 2005 Oct 13;7(21):4661-4. doi: 10.1021/ol051850s.
[reaction: see text] The enhancing effect of several photosensitizers in photoinitiated radical carbonylation is demonstrated and applied to accelerate the synthesis of compounds labeled with short-lived 11C. With the sensitizers, the synthesis of [carbonyl-11C]esters and acids from alkyl iodides, [11C]carbon monoxide, alcohols, and water provided up to 75-85% decay-corrected radiochemical yields in 6-min reactions under mild conditions. Acetone was used as a sensitizer in preparing 13C-substituted 1,10-decanedicarboxylic acid from (13C)carbon monoxide.
[反应：见正文] 证明了几种光敏剂在光引发自由基羰基化反应中的增强作用，并将其应用于加速标记有短寿命11C的化合物的合成。使用这些光敏剂，在温和条件下，由烷基碘、[11C]一氧化碳、醇和水合成[羰基-11C]酯和酸，在6分钟的反应中提供了高达75-85%的衰变校正放射化学产率。在由（13C）一氧化碳制备13C取代的1,10-癸二酸时，使用丙酮作为光敏剂。
