Salin-Pascual R J, Grandos-Fuentes D, Galicia-Polo L, Nieves E, Roehrs T A, Roth T
Sleep Disorders Center, Henry Ford Hospital, Detroit, Michigan.
Sleep. 1992 Jun;15(3):252-6. doi: 10.1093/sleep/15.3.252.
Sixteen subjects were assigned to a group using either placebo or biperiden, with eight subjects in each group. Both groups were studied for one acclimatization night, one baseline night, four nights of rapid eye movement (REM) sleep deprivation and two recovery nights. All the subjects received either placebo or 4 mg biperiden 1 hour before sleep during the four nights of REM sleep deprivation. During the baseline and the recovery nights both groups received placebo capsules. The results showed that REM sleep time during the REM sleep deprivation was reduced by 70-75% below the baseline night in both groups. The number of attempts to enter REM sleep was significantly reduced by biperiden as compared to placebo for each of the four REM sleep deprivation nights. Because the total sleep time in the biperiden group was reduced, the number of REM sleep attempts was corrected by the total sleep time. The adjusted number of REM sleep attempts was also significantly reduced in the biperiden group. REM sleep latency showed a reduction in the placebo group, whereas in the biperiden group REM sleep latency was unchanged throughout the deprivation nights. In the recovery night REM sleep time was increased in both groups, with no differences between the groups. The REM sleep latency showed a reduction in the first recovery night in both groups that persisted through the second recovery night. The above findings support the role of biperiden as a REM sleep suppressive drug.
16名受试者被分为两组，分别使用安慰剂或比哌立登，每组8名受试者。两组均进行了一个适应夜晚、一个基线夜晚、四个快速眼动（REM）睡眠剥夺夜晚和两个恢复夜晚的研究。在REM睡眠剥夺的四个夜晚，所有受试者在睡前1小时接受安慰剂或4毫克比哌立登。在基线和恢复夜晚，两组均接受安慰剂胶囊。结果显示，两组在REM睡眠剥夺期间的REM睡眠时间均比基线夜晚减少了70 - 75%。在四个REM睡眠剥夺夜晚中的每一个夜晚，与安慰剂相比，比哌立登显著减少了进入REM睡眠的尝试次数。由于比哌立登组的总睡眠时间减少，REM睡眠尝试次数通过总睡眠时间进行了校正。比哌立登组校正后的REM睡眠尝试次数也显著减少。安慰剂组的REM睡眠潜伏期缩短，而在比哌立登组，在整个剥夺夜晚REM睡眠潜伏期没有变化。在恢复夜晚，两组的REM睡眠时间均增加，两组之间没有差异。两组在第一个恢复夜晚的REM睡眠潜伏期均缩短，并持续到第二个恢复夜晚。上述发现支持了比哌立登作为一种REM睡眠抑制药物的作用。
