Salin-Pascual R J, Granados-Fuentes D, Galicia-Polo L, Nieves E, Echeverry J
Psychobiology Department, Mexican Institute of Psychiatry.
Neuropsychopharmacology. 1991 Sep;5(2):97-102.
Twenty-six healthy volunteers were randomly assigned to one of four groups. Groups Bip-4 and Bip-6, each with six subjects, received 4 and 6 mg of biperiden, respectively, and were studied on acclimatization, baseline, biperiden, and follow-up nights. Group REM-P (n = 7) and Group REM-Bip (n = 7) were studied on acclimatization, baseline, six nights of REM sleep deprivation, and one recovery (treatment) night with either placebo (group REM-P) or biperiden (group REM-Bip), and one follow-up night. Biperiden 4 and 6 mg increased REM sleep latency and biperiden 6 mg reduced REM sleep time. On the recovery night following REM sleep deprivation Group REM-P and REM-Bip showed an increase in sleep continuity. REM sleep time in the REM-P group was increased during the recovery (treatment) night (REM sleep recovery), while the REM-Bip group did not show a significant REM sleep increase during recovery (treatment) night. It was not until the follow-up night that REM sleep increased in the REM-Bip group.
26名健康志愿者被随机分为四组。Bip - 4组和Bip - 6组各有6名受试者，分别接受4毫克和6毫克的比哌立登，并在适应期、基线期、比哌立登用药期和随访期的夜晚进行研究。REM - P组（n = 7）和REM - Bip组（n = 7）在适应期、基线期、六个快速眼动睡眠剥夺夜晚以及一个恢复（治疗）夜晚进行研究，恢复（治疗）夜晚分别给予安慰剂（REM - P组）或比哌立登（REM - Bip组），并进行一个随访夜晚。4毫克和6毫克的比哌立登增加了快速眼动睡眠潜伏期，6毫克的比哌立登减少了快速眼动睡眠时间。在快速眼动睡眠剥夺后的恢复夜晚，REM - P组和REM - Bip组的睡眠连续性增加。REM - P组在恢复（治疗）夜晚的快速眼动睡眠时间增加（快速眼动睡眠恢复），而REM - Bip组在恢复（治疗）夜晚的快速眼动睡眠没有显著增加。直到随访夜晚，REM - Bip组的快速眼动睡眠才增加。
