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Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial.九价肺炎球菌结合疫苗对冈比亚肺炎和侵袭性肺炎球菌疾病的疗效：随机、双盲、安慰剂对照试验
Lancet. 2005;365(9465):1139-46. doi: 10.1016/S0140-6736(05)71876-6.
2
Approach to validating an opsonophagocytic assay for Streptococcus pneumoniae.验证肺炎链球菌调理吞噬试验的方法。
Clin Diagn Lab Immunol. 2005 Feb;12(2):287-95. doi: 10.1128/CDLI.12.2.287-295.2005.
3
Use of HL-60 cell line to measure opsonic capacity of pneumococcal antibodies.使用HL-60细胞系测量肺炎球菌抗体的调理吞噬能力。
Clin Diagn Lab Immunol. 2005 Jan;12(1):19-27. doi: 10.1128/CDLI.12.1.19-27.2005.
4
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Vaccine. 2004 Sep 28;22(29-30):4014-20. doi: 10.1016/j.vaccine.2004.03.049.
5
Long-term antibody levels and booster responses in South African children immunized with nonavalent pneumococcal conjugate vaccine.接种九价肺炎球菌结合疫苗的南非儿童的长期抗体水平和加强免疫反应
Vaccine. 2004 Jul 29;22(21-22):2696-700. doi: 10.1016/j.vaccine.2003.03.001.
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Impact of childhood vaccination on racial disparities in invasive Streptococcus pneumoniae infections.儿童疫苗接种对侵袭性肺炎链球菌感染种族差异的影响。
JAMA. 2004 May 12;291(18):2197-203. doi: 10.1001/jama.291.18.2197.
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Safety and immunogenicity of three doses of an eleven-valent diphtheria toxoid and tetanus protein--conjugated pneumococcal vaccine in Filipino infants.三剂十一价白喉类毒素和破伤风蛋白结合肺炎球菌疫苗在菲律宾婴儿中的安全性和免疫原性
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用于测量抗肺炎链球菌功能性抗体的荧光多价调理吞噬试验。

Fluorescent multivalent opsonophagocytic assay for measurement of functional antibodies to Streptococcus pneumoniae.

作者信息

Bieging Kathryn T, Rajam Gowrisankar, Holder Patricia, Udoff Ross, Carlone George M, Romero-Steiner Sandra

机构信息

Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.

出版信息

Clin Diagn Lab Immunol. 2005 Oct;12(10):1238-42. doi: 10.1128/CDLI.12.10.1238-1242.2005.

DOI:10.1128/CDLI.12.10.1238-1242.2005
PMID:16210490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1247838/
Abstract

We developed fluorescent mono- and multivalent opsonophagocytic assays (fOPA and fmOPA, respectively) specific for seven Streptococcus pneumoniae serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F). Bacterial survival was quantitated with alamar blue, a fluorescent metabolic indicator. Both fOPA and fmOPA allow for determination of viability endpoints for up to seven serotypes with high levels of agreement to the reference method. The fmOPA eliminates colony counting, reduces serum volume, and produces results in 1 day.

摘要

我们开发了分别针对七种肺炎链球菌血清型（4、6B、9V、14、18C、19F和23F）的荧光单价和多价调理吞噬试验（分别为fOPA和fmOPA）。用荧光代谢指示剂alamar blue对细菌存活率进行定量。fOPA和fmOPA都能确定多达七种血清型的活力终点，与参考方法的一致性很高。fmOPA无需进行菌落计数，减少了血清用量，并在1天内得出结果。