Sweeney J A, Haas G L, Li S
Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213.
Schizophr Bull. 1992;18(2):283-93. doi: 10.1093/schbul/18.2.283.
It is well known that neurobehavioral deficits are associated with schizophrenia. Little is known, however, about whether these disturbances becomes more severe over the course of the illness. In the present study, 101 patients with schizophrenia, of whom 45 were first-episode cases, performed pursuit eye tracking tasks. A subset of 60 of these patients, including 27 first-episode cases, were administered a battery of neuropsychological tests. Patients with a history of prior psychotic episodes demonstrated more severe pursuit eye movement dysfunction than first-episode patients and more severe disturbances on neuropsychological tests sensitive to prefrontal and left temporal cortical dysfunction. Longitudinal studies of patients ascertained close to the point of illness onset are needed to determine whether these findings reflect a progressive deterioration in neurobehavioral functioning over the course of schizophrenia.
众所周知，神经行为缺陷与精神分裂症有关。然而，对于这些障碍在疾病过程中是否会变得更加严重，人们却知之甚少。在本研究中，101名精神分裂症患者（其中45例为首发病例）进行了追踪眼球跟踪任务。这些患者中的60名（包括27例首发病例）接受了一系列神经心理学测试。有先前精神病发作史的患者比首发患者表现出更严重的追踪眼球运动功能障碍，并且在对前额叶和左颞叶皮质功能障碍敏感的神经心理学测试中表现出更严重的障碍。需要对接近疾病发作点确诊的患者进行纵向研究，以确定这些发现是否反映了精神分裂症病程中神经行为功能的进行性恶化。
