Oltolina A, Achilli A, Lodi G, Demarosi F, Sardella A
Department of Medicine, Surgery and Dentistry, San Paolo Hospital, University of Milan, Milan, Italy.
Minerva Stomatol. 2005 Jul-Aug;54(7-8):441-8.
A series of 5 patients with osteonecrosis of the jaws possibly related to the use of bisphosphonates is presented. A brief review of the literature is also proposed.
A retrospective review of patients who received bisphosphonates and who developed osteonecrosis of the jaws following minor oral surgery was performed.
In all 5 patients, a tooth extraction preceded the onset of osteonecrosis of the mandible. Patients were on chronic use of intravenous bisphosphonates. The presenting lesions was a nonhealing extraction socket and an exposed jawbone. Biopsy of the bone lesions showed no evidence of metastatic involvement. Antibiotic therapy, conservative debridement and, in some cases, bone sequestrectomy were performed.
Osteonecrosis of the jaws appears to have a relationship with the use of bisphosphonates. It is important that medical oncologists and dentists become aware of this possible complication in order to perform minor oral surgery prior to starting bisphosphonates treatment.
介绍5例可能与双膦酸盐类药物使用相关的颌骨骨坏死患者，并对相关文献进行简要回顾。
对接受双膦酸盐类药物治疗且在小型口腔手术后发生颌骨骨坏死的患者进行回顾性研究。
所有5例患者在下颌骨骨坏死发作前均进行了拔牙。患者长期静脉注射双膦酸盐类药物。出现的病变为拔牙创不愈合及颌骨暴露。骨病变活检未发现转移受累迹象。进行了抗生素治疗、保守清创，部分病例还进行了死骨切除术。
颌骨骨坏死似乎与双膦酸盐类药物的使用有关。重要的是，肿瘤内科医生和牙医应意识到这种可能的并发症，以便在开始双膦酸盐类药物治疗前进行小型口腔手术。
