Xu W X, Yu J R
Department of Physiology, Beijing Medical University.
Sheng Li Xue Bao. 1992 Apr;44(2):202-8.
Changes of concentration of serum glucose, insulin and glucagon induced by preadministration of indomethacin were observed in normal rats and diabetic rats induced by alloxan. The results demonstrated that the level of serum glucose in diabetic rats was lowered significantly after preadministration of indomethacin (10 mg/kg) dose-dependently. After preadministration of 5, 10, 15 mg/kg of indomethacin the level of serum glucose 48 h after injecting alloxan was decreased from the control value of 591.5 +/- 38.2 mg% to 559.1 +/- 53.2, 436 +/- 16.6 and 266.6 +/- 29.9 mg% respectively. The concentration of serum insulin was increased from the control 10.5 +/- 2.7 microU/ml to 31.9 +/- 7.0 microU/ml and glucagon from 550.0 +/- 27.0 pg/ml to 303.1 +/- 22.9 pg/ml after preadministration of 10 mg/kg indomethacin. Histologic observation showed that alloxan induced beta cell lesion in pancreatic islet could indeed be prevented by indomethacin to a significant extent.
观察了吲哚美辛预处理对正常大鼠和四氧嘧啶诱导的糖尿病大鼠血清葡萄糖、胰岛素和胰高血糖素浓度的影响。结果表明，糖尿病大鼠在给予吲哚美辛（10mg/kg）预处理后，血清葡萄糖水平显著降低，且呈剂量依赖性。给予5、10、15mg/kg吲哚美辛预处理后，注射四氧嘧啶48小时后的血清葡萄糖水平分别从对照值591.5±38.2mg%降至559.1±53.2、436±16.6和266.6±29.9mg%。给予10mg/kg吲哚美辛预处理后，血清胰岛素浓度从对照的10.5±2.7μU/ml升至31.9±7.0μU/ml，胰高血糖素从550.0±27.0pg/ml降至303.1±22.9pg/ml。组织学观察表明，吲哚美辛确实能在很大程度上预防四氧嘧啶诱导的胰岛β细胞损伤。
