Smith Catherine J, Tsang Melanie W S, Holmes Andrew B, Danheiser Rick L, Tester Jefferson W
Melville Laboratory, Department of Chemistry, Lensfield Road, Cambridge, UKCB2 1EW.
Org Biomol Chem. 2005 Oct 21;3(20):3767-81. doi: 10.1039/b509345g. Epub 2005 Sep 13.
Palladium catalysed C-N bond formation in supercritical carbon dioxide has been accomplished. Carbamic acid formation is avoided in part through the use of an N-silylamine as the coupling partner. Employing a catalyst system of Pd2dba3(1 mol%) and 2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl (X-Phos)(2 mol%) enabled the catalytic amination of aryl bromides and chlorides with N-silylanilines to be realised in excellent yield. Extension of the methodology to the N-arylation of N-silyldiarylamines, N-silylazoles and N-silylsulfonamides is reported.
钯催化在超临界二氧化碳中形成碳 - 氮键已得以实现。通过使用N - 硅烷基胺作为偶联伙伴，部分避免了氨基甲酸的形成。采用Pd2dba3（1摩尔％）和2 - 二环己基膦基 - 2'，4'，6' - 三异丙基 - 1,1' - 联苯（X - Phos）（2摩尔％）的催化剂体系，能够以优异的产率实现芳基溴化物和氯化物与N - 硅烷基苯胺的催化胺化反应。本文报道了该方法扩展至N - 硅烷基二芳基胺、N - 硅烷基唑和N - 硅烷基磺酰胺的N - 芳基化反应。
