唾液皮质醇测量的临床应用。

Clinical applications of salivary cortisol measurements.

作者信息

Lo M S, Ng M L, Azmy B S, Khalid B A

机构信息

Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur.

出版信息

Singapore Med J. 1992 Apr;33(2):170-3.

PMID:1621122

Abstract

The clinical applications of salivary cortisol measurements were evaluated by radioimmunoassay of time-matched saliva and plasma samples. Salivary cortisol levels of normal subjects exhibited a significant (p less than 0.001) diurnal variation with a mean (+/- SD) concentration of 8.7 +/- 4.8 nmol/L at 0800-1000 h and 2.4 +/- 1.1 nmol/l at 1500-1700 h. After an overnight dexamethasone suppression test, morning salivary cortisol levels decrease to 2.7 +/- 0.7 nmol/L (p less than 0.001 vs normal). An excellent correlation (r = 0.805) of cortisol measurements with time-matched saliva and plasma samples was obtained (y = 0.03x + 0.88, p less than 0.001, n = 91). Hypercortisolism was confirmed by raised salivary cortisols in only half of patients with elevated total plasma levels, thereby indicating that salivary cortisol measurements is a better index of adrenal status.

摘要

通过对时间匹配的唾液和血浆样本进行放射免疫测定，评估唾液皮质醇测量的临床应用。正常受试者的唾液皮质醇水平呈现出显著（p<0.001）的昼夜变化，08:00 - 10:00时的平均（±标准差）浓度为8.7±4.8 nmol/L，15:00 - 17:00时为2.4±1.1 nmol/L。过夜地塞米松抑制试验后，早晨唾液皮质醇水平降至2.7±0.7 nmol/L（与正常相比，p<0.001）。时间匹配的唾液和血浆样本的皮质醇测量结果具有极好的相关性（r = 0.805）（y = 0.03x + 0.88，p<0.001，n = 91）。仅一半总血浆水平升高的患者唾液皮质醇升高证实了皮质醇增多症，从而表明唾液皮质醇测量是肾上腺状态的更好指标。