Dabrosin Charlotta
Division of Gynecologic Oncology, University Hospital, Faculty of Health Sciences, Linköping, Sweden.
Angiogenesis. 2005;8(2):127-36. doi: 10.1007/s10456-005-9002-0. Epub 2005 Oct 7.
Angiogenesis is essential for normal function in the female reproductive tract and a prerequisite for growth and metastasis of solid tumors. Several factors, both inducers and inhibitors, play essential roles in the regulation of the angiogenic process. Exposure to sex steroids increases the risk of breast cancer but the mechanisms are poorly understood and the importance of angiogenesis in breast carcinogenesis is undefined. In the female reproductive tract ovarian hormones tightly regulate angiogenesis. The breast is also a target organ for sex steroids but very little is known about sex steroid effects on angiogenesis in normal breast tissue and breast cancer. In this review several regulators of angiogenesis, and their relation to sex steroids, in breast tissue are discussed. Increased knowledge in this area is of utmost importance for future therapeutic treatment options and for breast cancer prevention.
血管生成对于女性生殖道的正常功能至关重要，也是实体瘤生长和转移的先决条件。多种因素，包括诱导剂和抑制剂，在血管生成过程的调节中发挥着重要作用。接触性类固醇会增加患乳腺癌的风险，但其机制尚不清楚，血管生成在乳腺癌发生中的重要性也不明确。在女性生殖道中，卵巢激素严格调节血管生成。乳腺也是性类固醇的靶器官，但关于性类固醇对正常乳腺组织和乳腺癌血管生成的影响知之甚少。在这篇综述中，讨论了乳腺组织中几种血管生成调节因子及其与性类固醇的关系。该领域知识的增加对于未来的治疗选择和乳腺癌预防至关重要。
