Trillenberg Peter, Führer Julia, Sprenger Andreas, Hagenow Ania, Kömpf Detlef, Wenzelburger Roland, Deuschl Günther, Heide Wolfgang, Helmchen Christoph
Department of Neurology, University Hospital of Schleswig-Holstein, Lübeck, Germany.
Mov Disord. 2006 Mar;21(3):373-9. doi: 10.1002/mds.20729.
Patients with essential tremor (ET) or with cerebellar lesions have in common oculomotor abnormalities, with the exception of saccadic eye movements, which do not seem to be involved in ET. Since grasping is prolonged in ET and might be related to saccadic dysmetria, we tested whether simultaneous hand pointing could unmask it. Twelve ET patients and 14 controls performed saccades with and without simultaneous pointing movements to the same targets, and with and without a gap between the disappearance of the fixation point and the appearance of the target. Eye movements were recorded with the magnetic search-coil method, hand movements with an ultrasound-emitting probe. ET patients did not have saccadic dysmetria, and contrary to normal subjects their saccadic latency did not decrease during combined eye-hand movements compared with saccades performed in isolation. Hand movements had a longer duration in ET patients, with decreased peak acceleration, an increased latency of the peak velocity, and peak deceleration. In conclusion, this first study on eye-hand coordination in ET revealed abnormal kinematic changes in the early phase of pointing movements. These changes might be related to cerebellar disease but they are independent of the intention tremor component and saccade performance.
原发性震颤（ET）患者或小脑病变患者存在共同的眼球运动异常，但扫视眼动除外，扫视眼动似乎与ET无关。由于ET患者的抓握动作延长，且可能与扫视辨距不良有关，我们测试了同时进行手部指向动作是否会使其显现出来。12名ET患者和14名对照者在有或没有同时指向相同目标动作的情况下进行扫视，且在固定点消失和目标出现之间有或没有间隔。用磁搜索线圈法记录眼动，用超声发射探头记录手部动作。ET患者没有扫视辨距不良，与正常受试者相反，与单独进行扫视相比，他们在眼手联合运动期间的扫视潜伏期没有缩短。ET患者的手部动作持续时间更长，峰值加速度降低，峰值速度潜伏期增加，峰值减速度增加。总之，这项关于ET患者眼手协调的首次研究揭示了指向动作早期阶段的异常运动学变化。这些变化可能与小脑疾病有关，但它们独立于意向性震颤成分和扫视表现。
