Kuru Bekir, Dinc Soykan, Elitok Orhan, Gulcelik Mehmet Ali, Alagol Haluk
Department of General Surgery, Ankara Oncology Education and Research Hospital, Turkey.
Scand J Plast Reconstr Surg Hand Surg. 2005;39(4):193-6.
Our objective was to find out whether granulocyte-macrophage colony-stimulating factor (GM-CSF) improves the survival of skin flaps in rats. Random skin flaps were raised in 30 male Sprague-Dawley rats, and recombinant GM-CSF 50 microg in 0.5 ml saline solution (n=15) or 0.5 ml saline solution alone (n=15) was injected intradermally into the area of the flap after it had been raised. Surviving areas were measured after seven days, and the median area surviving in the group treated with GM-CSF was greater than that in the control group (728 mm2 (range 565-1120) compared with 985 mm2 (range 636-1368), p=0.005). These results suggest that in this model, GM-CSF given postoperatively improves the viability of ischaemic skin flaps.
我们的目的是探究粒细胞巨噬细胞集落刺激因子（GM-CSF）是否能提高大鼠皮瓣的存活率。在30只雄性Sprague-Dawley大鼠身上掀起随意皮瓣，皮瓣掀起后，将含50微克重组GM-CSF的0.5毫升盐溶液（n = 15）或仅0.5毫升盐溶液（n = 15）皮内注射到皮瓣区域。7天后测量存活面积，GM-CSF治疗组的中位存活面积大于对照组（分别为728平方毫米（范围565 - 1120）和985平方毫米（范围636 - 1368），p = 0.005）。这些结果表明，在此模型中，术后给予GM-CSF可提高缺血皮瓣的活力。
