Cigudosa J C, Calasanz M J, Gullón A, Cuesta B, Rifón J, Rocha E
Departamento de Genética, Universidad de Navarra, Clínica Universitaria, Pamplona.
Sangre (Barc). 1992 Apr;37(2):125-7.
A 35-year-old Spanish female having acute myelomonocytic leukaemia with marrow eosinophilia is reported. The karyotype revealed the specific chromosomal abnormality associated with this disorder, inv(16), and a less-specific myelodysplastic cytogenetic marker, del(12p). We have reviewed the published cases in order to elucidate the possible significance of presenting a 12p deletion (nonrandomly associated with chronic myelomonocytic leukaemia) together with other chromosomal rearrangements.
报告了一名35岁患有急性粒单核细胞白血病伴骨髓嗜酸性粒细胞增多的西班牙女性。核型分析显示了与该疾病相关的特定染色体异常，即inv(16)，以及一个特异性较低的骨髓发育异常细胞遗传学标记，del(12p)。我们回顾了已发表的病例，以阐明出现12号染色体短臂缺失（与慢性粒单核细胞白血病非随机相关）以及其他染色体重排的可能意义。
