Wang Yen-Ho, Huang Tien-Shang, Liang Huey-Wen, Su Ta-Chen, Chen Ssu-Yuan, Wang Tzung-Dau
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Arch Phys Med Rehabil. 2005 Oct;86(10):1964-8. doi: 10.1016/j.apmr.2005.04.017.
To measure serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury (SCI) and to investigate possible correlations between these serum levels and various factors, such as body mass index (BMI), age, injury level, and duration of injury.
Cross-sectional.
A university hospital that is a tertiary referral center.
Eighty-nine men with traumatic neurologically complete SCI (30 with tetraplegia, 59 with paraplegia) and 37 age- and BMI-matched male controls. Subjects with SCI were injured at the mean age +/- standard error of 28.5+/-1.0 years (range, 14.7-59.1 y) and the mean injury duration was 10.8+/-0.7 years (range, 1.1-27.7 y).
Not applicable.
Serum levels of adiponectin, ghrelin, and leptin and BMI.
Serum leptin levels in subjects with SCI (mean, 7.0+/-0.5 mg/mL) [corrected] were significantly higher than those in able-bodied controls (mean, 4.7+/-0.6 mg/mL) [corrected] (P<.01). The group with tetraplegia had higher serum leptin levels than the group with paraplegia, but this did not reach a statistically significant level (8.2+/-1.1 ng/mL vs 6.4+/-0.5 mg/mL [corrected] P=.097). There were significant differences in serum leptin levels among the 3 groups by 1-way analysis of variance (P=.008). Serum adiponectin levels in subjects with SCI (7.1+/-0.5 mg/mL) [corrected] were higher than those in able-bodied controls (5.6+/-0.5 mg/mL) [corrected] but this was not statistically significant (P=.08). In contrast, serum levels of ghrelin in subjects with SCI (302.0+/-17.5 pg/mL) were similar to those in the controls (264.0+/-27.0 pg/mL) (P=.24). Serum leptin levels correlated positively with BMI (SCI, r=.698, P<.001; controls, r=.782, P<.001), whereas serum adiponectin (SCI, r=-.527, P<.001; controls, r=-.315, P=.057) and ghrelin (SCI, r=-.368, P<.001; controls, r=-.447, P=.006) levels correlated negatively with the BMI in both subjects with SCI and controls.
Men with SCI have significantly higher serum leptin levels than able-bodied controls, and serum leptin levels correlated with the degree of neurologic deficit. Men with SCI had a tendency toward higher serum adiponectin level than able-bodied controls. Serum levels of ghrelin in men with SCI were similar to those of controls.
测量脊髓损伤（SCI）男性患者血清脂联素、胃饥饿素和瘦素水平，并研究这些血清水平与各种因素（如体重指数（BMI）、年龄、损伤平面和损伤持续时间）之间的可能相关性。
横断面研究。
一所大学医院，为三级转诊中心。
89例创伤性神经完全性SCI男性患者（30例四肢瘫，59例截瘫）和37例年龄及BMI匹配的男性对照者。SCI患者受伤时的平均年龄为28.5±1.0岁（范围14.7 - 59.1岁），平均损伤持续时间为10.8±0.7年（范围1.1 - 27.7年）。
不适用。
血清脂联素、胃饥饿素、瘦素水平及BMI。
SCI患者血清瘦素水平（均值7.0±0.5mg/mL）[校正后]显著高于健康对照者（均值4.7±0.6mg/mL）[校正后]（P<0.01）。四肢瘫组血清瘦素水平高于截瘫组，但未达到统计学显著水平（8.2±1.1ng/mL对6.4±0.5mg/mL[校正后]，P = 0.097）。经单因素方差分析，3组间血清瘦素水平存在显著差异（P = 0.008）。SCI患者血清脂联素水平（7.1±0.5mg/mL）[校正后]高于健康对照者（5.6±0.5mg/mL）[校正后]，但差异无统计学意义（P = 0.08）。相比之下，SCI患者血清胃饥饿素水平（302.0±17.5pg/mL）与对照者（264.0±27.0pg/mL）相似（P = 0.24）。血清瘦素水平与BMI呈正相关（SCI患者，r = 0.698，P<0.001；对照者，r = 0.782，P<0.001），而血清脂联素（SCI患者，r = -0.527，P<0.001；对照者，r = -0.315，P = 0.057）和胃饥饿素（SCI患者，r = -0.368，P<0.001；对照者，r = -0.447，P = 0.006）水平在SCI患者和对照者中均与BMI呈负相关。
SCI男性患者血清瘦素水平显著高于健康对照者，且血清瘦素水平与神经功能缺损程度相关。SCI男性患者血清脂联素水平有高于健康对照者的趋势。SCI男性患者血清胃饥饿素水平与对照者相似。
