肾再次移植与首次肾移植的比较。

Kidney retransplantation in comparison with first kidney transplantation.

作者信息

Pour-Reza-Gholi F, Nafar M, Saeedinia A, Farrokhi F, Firouzan A, Simforoosh N, Basiri A, Einollahi B

机构信息

Urology and Nephrology Research Center, Shaheed Labbafinejad Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Transplant Proc. 2005 Sep;37(7):2962-4. doi: 10.1016/j.transproceed.2005.08.034.

DOI:10.1016/j.transproceed.2005.08.034

PMID:16213274

Abstract

INTRODUCTION

The aim of this study was to depict the outcome of second and third kidney allografts in comparison with first kidney allografts.

METHODS

Among 2150 kidney transplantations are 103 second and 5 third transplantations. Demographic characteristics and survivals of retransplanted patients were compared with a randomly selected group of first kidney recipients, consisting of two cases matched with each retransplanted patient for age, gender, and date of transplantation.

RESULTS

Retransplanted patients consisted of 78 men and 30 women of mean age 32.63 +/- 11.92 years. They had received kidneys from 91 living-unrelated and 17 living-related donors. Median followup was 27 months. One-, 2-, 3-, and 5-year graft survivals were 81.4%, 78.9%, 78.9%, and 73.7% among retransplants, versus 92.9%, 91.5%, 89.8%, and 85.3% in the control group, respectively (P = .0037). Patient survival was 96%, 94.6%, 92.4%, and 87.8% in the retransplant group versus 93.1%, 92.4%, 90.9%, 87.4% in the control group, respectively (P = .63). Also, graft survivals were slightly lower in female compared to male retransplant patients (P = .09). No significant difference in survival rates was seen in different age groups.

CONCLUSION

It seems that kidney retransplantation can yield desirable outcomes, albeit relatively lower graft survivals.

摘要

引言

本研究的目的是描述第二次和第三次肾移植与首次肾移植相比的结果。

方法

在2150例肾移植中，有103例第二次移植和5例第三次移植。将再次移植患者的人口统计学特征和生存率与随机选择的首次肾移植受者组进行比较，该组由两名在年龄、性别和移植日期上与每名再次移植患者匹配的病例组成。

结果

再次移植患者包括78名男性和30名女性，平均年龄32.63±11.92岁。他们接受了来自91名非亲属活体供者和17名亲属活体供者的肾脏。中位随访时间为27个月。再次移植患者的1年、2年、3年和5年移植肾生存率分别为81.4%、78.9%、78.9%和73.7%，而对照组分别为92.9%、91.5%、89.8%和85.3%（P = 0.0037）。再次移植组的患者生存率分别为96%、94.6%、92.4%和87.8%，对照组分别为93.1%、92.4%、90.9%和87.4%（P = 0.63）。此外，女性再次移植患者的移植肾生存率略低于男性（P = 0.09）。不同年龄组的生存率未见显著差异。