Dalgic A, Moray G, Emiroglu R, Sozen H, Karakayali H, Boyacioglu S, Bilgin N, Haberal M
Baskent University, Department of General Surgery, Transplantation Unit, Ankara, Turkey.
Transplant Proc. 2005 Sep;37(7):3137-40. doi: 10.1016/j.transproceed.2005.08.046.
Biliary complications after living-related liver transplantation (LRLT) remain a major source of morbidity for recipients. We describe our technique and early results with 32 recipients who underwent LRLT with duct-to-duct anastomoses during the last 2 years.
Between January 2003 and December 2004, 50 patients underwent liver transplantation in our center with overall patient and graft survival rate of 86.4% and 86.4%. Of 50 patients, 41 (82.0%; 17 adult and 24 pediatric) underwent LRLT, 32 (78.0%) of whom had duct-to-duct biliary anastomoses with a "corner-saving suture" technique.
Of 32 patients in whom duct-to-duct biliary anastomoses were performed, 4 (12.5%) had an anastomotic leak with 2 eventually developing bile duct strictures within 3 months. One patient required reoperation for a bile leak. All other anastomotic leaks and strictures were treated with percutaneous drainage and balloon dilatation with excellent outcomes. There was no long-term morbidity and no graft loss owing to biliary complications. Seven patients died during follow-up (0.5 to 25 months); 43 are doing well with optimal liver function in the early posttransplantation period.
According to our early results, we recommend duct-to-duct anastomosis in LRLT when calibration of the ducts show suitable results and when there is no tension on the anastomosis site. Otherwise, Roux-en-Y hepaticojejunostomy should be performed to decrease risk of biliary complications.
亲属活体肝移植(LRLT)后的胆道并发症仍是受者发病的主要原因。我们描述了过去两年中32例接受LRLT并采用端端胆管吻合术的受者的技术及早期结果。
2003年1月至2004年12月,50例患者在我们中心接受肝移植,患者和移植物总体生存率分别为86.4%和86.4%。50例患者中,41例(82.0%;17例成人和24例儿童)接受了LRLT,其中32例(78.0%)采用“保角缝合”技术进行了端端胆管吻合。
在进行端端胆管吻合的32例患者中,4例(12.5%)发生吻合口漏,其中2例最终在3个月内出现胆管狭窄。1例患者因胆漏需要再次手术。所有其他吻合口漏和狭窄均采用经皮引流和球囊扩张治疗,效果良好。没有因胆道并发症导致的长期发病和移植物丢失。7例患者在随访期间(0.5至25个月)死亡;43例在移植后早期肝功能良好。
根据我们的早期结果,当胆管校准显示合适结果且吻合部位无张力时,我们建议在LRLT中采用端端吻合术。否则,应进行Roux-en-Y肝空肠吻合术以降低胆道并发症的风险。