Weigert Johanna, Neumeier Markus, Schäffler Andreas, Fleck Martin, Schölmerich Jürgen, Schütz Christian, Buechler Christa
Department of Internal Medicine I, University of Regensburg, Germany.
FEBS Lett. 2005 Oct 24;579(25):5565-70. doi: 10.1016/j.febslet.2005.09.022. Epub 2005 Sep 28.
The adiponectin paralog CORS-26 (collagenous repeat-containing sequence of 26kDa protein) is a member of the C1q/TNF-alpha molecular superfamily. CORS-26 is a secreted protein and baculovirus-produced CORS-26 released in the supernatant of insect cells forms stable trimers. Adiponectin exerts anti-inflammatory effects in LPS-treated monocytic cells and CORS-26 also reduces IL-6 and TNF-alpha secretion but does not increase IL-10. Suppression of NFkappaB signalling may explain the anti-inflammatory actions of CORS-26. Furthermore CORS-26 protein was detected in human monocytic and dendritic cells. The present data demonstrate for the first time that CORS-26 forms trimers, exerts anti-inflammatory properties and that it is expressed in monocytic cells. Therefore CORS-26 may provide a new target for pharmacological drugs in inflammatory diseases like the metabolic syndrome.
脂联素旁系同源物CORS-26（含26kDa蛋白质胶原重复序列）是C1q/TNF-α分子超家族的成员。CORS-26是一种分泌蛋白，在昆虫细胞上清液中由杆状病毒产生的CORS-26形成稳定的三聚体。脂联素在LPS处理的单核细胞中发挥抗炎作用，CORS-26也可减少IL-6和TNF-α的分泌，但不会增加IL-10。NFκB信号通路的抑制可能解释了CORS-26的抗炎作用。此外，在人单核细胞和树突状细胞中检测到了CORS-26蛋白。目前的数据首次证明CORS-26形成三聚体，具有抗炎特性，且在单核细胞中表达。因此，CORS-26可能为代谢综合征等炎症性疾病的药物治疗提供新的靶点。
