Lee C C, Lin W T, Liao P C, Su H J, Chen H L
Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan.
Environ Pollut. 2006 May;141(2):381-6. doi: 10.1016/j.envpol.2005.08.032. Epub 2005 Oct 6.
An abandoned pentachlorophenol plant and nearby area in southern Taiwan was heavily contaminated by dioxins, impurities formed in the PCP production process. The investigation showed that the average serum PCDD/Fs of residents living nearby area (62.5 pg WHO-TEQ/g lipid) was higher than those living in the non-polluted area (22.5 and 18.2 pg WHO-TEQ/g lipid) (P<0.05). In biota samples, average PCDD/F of milkfish in sea reservoir (28.3 pg WHO-TEQ/g) was higher than those in the nearby fish farm (0.15 pg WHO-TEQ/g), and Tilapia and shrimp showed the similar trend. The average daily PCDD/Fs intake of 38% participants was higher than 4 pg WHO-TEQ/kg/day suggested by the world health organization. Serum PCDD/F was positively associated with average daily intake (ADI) after adjustment for age, sex, BMI, and smoking status. In addition, a prospective cohort study is suggested to determine the long-term health effects on the people living near factory.
台湾南部一家废弃的五氯苯酚工厂及其附近地区受到二噁英的严重污染，二噁英是五氯苯酚生产过程中形成的杂质。调查显示，居住在附近地区居民的血清多氯二苯并二噁英/多氯二苯并呋喃平均含量（62.5皮克WHO-TEQ/克脂质）高于居住在未受污染地区居民的含量（22.5和18.2皮克WHO-TEQ/克脂质）（P<0.05）。在生物群样本中，海水水库中虱目鱼的多氯二苯并二噁英/多氯二苯并呋喃平均含量（28.3皮克WHO-TEQ/克）高于附近养鱼场中虱目鱼的含量（0.15皮克WHO-TEQ/克），罗非鱼和虾也呈现类似趋势。38%参与者的多氯二苯并二噁英/多氯二苯并呋喃日均摄入量高于世界卫生组织建议的4皮克WHO-TEQ/千克/天。在对年龄、性别、体重指数和吸烟状况进行调整后，血清多氯二苯并二噁英/多氯二苯并呋喃与日均摄入量呈正相关。此外，建议开展一项前瞻性队列研究，以确定对居住在工厂附近人群的长期健康影响。
