Verma Rajeshwar P, Hansch Corwin
Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
Bioorg Med Chem. 2006 Feb 15;14(4):982-96. doi: 10.1016/j.bmc.2005.09.016. Epub 2005 Oct 6.
Influenza is a major respiratory infection associated with significant morbidity in the general population and mortality in elderly and high-risk patients. It is an RNA virus that contains two major surface glycoproteins, neuraminidase and hemagglutinin. These proteins are essential for infection. Neuraminidase has been found to be a potential target to control influenza virus. In this paper, we have developed 17 quantitative structure-activity relationships (QSAR) for different sets of compounds to understand chemical-biological interactions governing their activities toward influenza neuraminidase.
流感是一种主要的呼吸道感染疾病，在普通人群中会引发较高的发病率，在老年人和高危患者中会导致死亡。它是一种RNA病毒，包含两种主要的表面糖蛋白，即神经氨酸酶和血凝素。这些蛋白质对于感染至关重要。神经氨酸酶已被发现是控制流感病毒的一个潜在靶点。在本文中，我们针对不同的化合物集开发了17种定量构效关系（QSAR），以了解支配它们对流感神经氨酸酶活性的化学-生物学相互作用。
