两人之“T”：当助人者需要帮助时。

T for two: when helpers need help.

作者信息

Zanetti Maurizio

机构信息

The Laboratory of Immunology, Department of Medicine and Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0837, USA.

出版信息

Autoimmun Rev. 2005 Nov;4(8):571-8. doi: 10.1016/j.autrev.2005.04.001.

DOI:10.1016/j.autrev.2005.04.001

PMID:16214098

Abstract

This article discusses forms of cell cooperation involving CD4 T cells and their impact on adaptive immunity. In particular, evidence will be presented in favor of cooperation among CD4 T cells of different specificity, its molecular basis and functional significance. Th-Th cooperation, or help for helpers, will be discussed in relation to the induction of anti-tumor responses and, in converse, the generation of autoimmunity. A model is proposed where Th-Th cooperation may represent the structure/function substrate for the control of self/non-self discrimination and peripheral tolerance in vivo.

摘要

本文讨论了涉及CD4 T细胞的细胞合作形式及其对适应性免疫的影响。特别是，将提供证据支持不同特异性的CD4 T细胞之间的合作、其分子基础和功能意义。将讨论Th-Th合作，即辅助细胞之间的帮助，与抗肿瘤反应的诱导相关，反之，与自身免疫的产生相关。提出了一个模型，其中Th-Th合作可能代表体内自我/非自我识别和外周耐受控制的结构/功能基础。