The Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-081, USA.
Crit Rev Immunol. 2020;40(3):255-262. doi: 10.1615/CritRevImmunol.2020034859.
This article is a tribute to Eli Sercarz and draws on his proposal of a hierarchical order of T-cell determinants in antigen presentation and T-cell activation. Here I revisit the concept of dominance and crypticity in the context of lymphocyte cooperation in the generation of the adaptive immune response, with emphasis on Th-Th cooperation. The remarks made in this article serve as a basis for a reassessment of the unresponsiveness of self-tumor antigens and how to leverage cryptic T-cell determinants operationally to generate antitumor T-cell immunity.
这是一篇向 Eli Sercarz 致敬的文章，内容取自他提出的 T 细胞决定簇在抗原呈递和 T 细胞激活中的分级秩序。在此，我重新审视了在适应性免疫反应中淋巴细胞协同作用的背景下，优势和隐匿性的概念，重点是 Th-Th 协同作用。本文中的论述为重新评估自身肿瘤抗原的无反应性以及如何利用隐匿性 T 细胞决定簇来产生抗肿瘤 T 细胞免疫提供了基础。
