Huang Sheng-Hsien, Chen Rong-Hsing, Wan Lei, Tsai Fuu-Jen, Chen Wen-Chi
Division of Urology, Department of Surgery, Changhua Christian Hospital, and Postgraduate Institute of Medical Research, China Medical University, Taichung, Taiwan.
Urol Int. 2005;75(3):264-8. doi: 10.1159/000087806.
Inflammation might be one of the causes of stone disease. The function of the transporter associated with antigen-processing protein (TAP) is related to immune response and inflammation. Our aim was to investigate the relationship between stone disease and 5 polymorphic sites of the TAP gene (TAP1-1, 1-2, 2-1, 2-2, 2-3).
We compared the frequencies of 5 polymorphisms in the TAP gene between 208 patients with recurrent calcium oxalate stone and 210 healthy controls. The polymorphism was detected by polymerase chain reaction-based restriction analysis.
Significant differences in the frequency of the polymorphism at the TAP2-2 site were detected between normal individuals and calcium stone disease patients (p<0.0001). The distribution of the genotype AA homozygote was higher in stone patients (33.3%) than in the control group (16.3%). The odds ratio for the A allele compared with the G allele was 2.097 (95% CI 1.571-2.802).
We conclude that the TAP2-2 MspI polymorphism might be associated with calcium stone disease.
