Santoro V, Caputo G, Peluso F
Unit of Maxillofacial Surgery and Dentistry, S. Sebastiano Hospital, Caserta, Italy.
Minerva Stomatol. 2005 Sep;54(9):489-96.
Burning mouth syndrome (BMS) is a chronic painful syndrome in clinically normal oral mucosa. There are many local, systemic and/or psychogenic pathological conditions that may clinically appear as burning and painful sensation of the oral mucosa. There are essential or idiopathic BMS and organic or secondary BMS. A diagnostic and therapeutic protocol is proposed by the authors evaluating, the effectiveness of the estroprogestinic replacement therapy in post-menopausal women suffering from idiopathic BMS.
A total of 28 patients suffering from persistent burning and painful oral sensation underwent to careful clinical and laboratory examination in order to distinguish primary forms from secondary ones. Patients suffering from primary BMS underwent to incisional biopsy for the research of estrogens receptors.
Only 8 out of the 28 studied patients (28.5%) were negative to the clinical oral and laboratory examinations listed in our protocol and they were diagnosed for primary BMS. All of them were females.
The use of a valid diagnostic and therapeutic protocol allows a better management of patients suffering from oral pain and a reduction if not a disappearance of the burning symptomatology in most of them. In post-menopausal patients suffering from idiopathic BMS good results may be obtained by an estroprogestinic replacement therapy.
灼口综合征（BMS）是一种发生于临床正常口腔黏膜的慢性疼痛综合征。有许多局部、全身和/或心理性病理状况在临床上可能表现为口腔黏膜的烧灼感和疼痛感。灼口综合征有原发性或特发性BMS以及器质性或继发性BMS。作者提出了一种诊断和治疗方案，评估雌孕激素替代疗法对患有特发性BMS的绝经后女性的有效性。
共有28例患有持续性口腔烧灼感和疼痛的患者接受了仔细的临床和实验室检查，以区分原发性和继发性形式。患有原发性BMS的患者接受了切开活检以研究雌激素受体。
在28例研究患者中，只有8例（28.5%）对我们方案中列出的临床口腔和实验室检查呈阴性，他们被诊断为原发性BMS。所有患者均为女性。
使用有效的诊断和治疗方案可以更好地管理口腔疼痛患者，并在大多数患者中减轻甚至消除烧灼感症状。对于患有特发性BMS的绝经后患者，雌孕激素替代疗法可能会取得良好效果。
