Pawluski Jodi L, Galea Liisa A M
Program in Neuroscience, Department of Psychology and Brain Research Center, University of British Columbia, 2136 West Mall, Vancouver, BC, V6T 1Z4, Canada.
J Neurobiol. 2006 Jan;66(1):71-81. doi: 10.1002/neu.20194.
Pregnancy and mothering result in a number of hormonal, neurological, and behavioral changes that are necessary to ensure reproductive success. With subsequent reproductive experience (multiparity and mothering), further neurological and behavioral changes may result. Recent research has shown that previous motherhood enhances both hippocampus-dependent learning and memory and long-term potentiation (LTP); together with decreases in hippocampus volumes during pregnancy it is suggested that the hippocampus is affected by pregnancy and/or mothering. The present experiment aimed to investigate the effect of reproductive experience (nulli, primi-, and multiparity and mothering) on dendritic morphology in the CA1 and CA3 regions of the hippocampus. Brains were stained with a modified version of the single-section Golgi impregnation technique, and dendritic length, number of branch points, and spine density was analyzed for apical and basal regions of CA1 and CA3 pyramidal neurons. Primiparity and/or mothering resulted in dendritic remodeling in both the CA1 and CA3 hippocampal regions, and multiparity resulted in enhanced spine density in the basal CA1 region, which was positively correlated with number of male pups in a litter. These findings point to the effect of reproductive experience and offspring on plasticity in the hippocampus, an area not traditionally associated with motherhood.
怀孕和成为母亲会导致一些激素、神经和行为上的变化，这些变化对于确保生殖成功是必要的。随着后续的生殖经历（多胎生育和育儿），可能会出现进一步的神经和行为变化。最近的研究表明，先前的母亲身份会增强海马体依赖的学习和记忆以及长时程增强（LTP）；再加上怀孕期间海马体体积减小，表明海马体受到怀孕和/或育儿的影响。本实验旨在研究生殖经历（未生育、初产和多胎生育以及育儿）对海马体CA1和CA3区域树突形态的影响。大脑用改良的单切片高尔基浸染技术进行染色，并分析CA1和CA3锥体神经元顶端和基部区域的树突长度、分支点数和棘密度。初产和/或育儿导致海马体CA1和CA3区域的树突重塑，多胎生育导致基部CA1区域的棘密度增加，这与一窝中雄性幼崽的数量呈正相关。这些发现表明生殖经历和后代对海马体可塑性的影响，而海马体是一个传统上与母亲身份无关的区域。
