Bono F, Giliberto C, Mastrandrea C, Cristiano D, Lavano A, Fera F, Quattrone A
Institutes of Neurology, University Magna Graecia, Catanzaro, Italy.
Neurology. 2005 Oct 11;65(7):1090-3. doi: 10.1212/01.wnl.0000178889.63571.e5.
Bilateral transverse sinus (TS) stenosis has been found in more than 90% of patients with idiopathic intracranial hypertension (IIH).
To evaluate whether TS stenosis changed after normalization of CSF pressure in patients with IIH during medical treatment.
Fourteen consecutive patients with IIH with bilateral TS stenosis on cerebral MR venography (MRV) during the medical treatment were studied. Patients were followed for over a 6-year period. During the follow-up, patients underwent repeated lumbar punctures (LPs) and cerebral MRV. MRV was always performed before each LP.
TS stenosis persisted in all the patients during the follow-up. In 9 of 14 (64%) patients with IIH, CSF pressure normalized during medical treatment.
Transverse sinus (TS) stenoses, as revealed by MR venography, persist in patients with idiopathic intracranial hypertension after normalization of CSF pressure, suggesting the lack of a direct relationship between the caliber of TS and CSF pressure.
超过90%的特发性颅内高压(IIH)患者存在双侧横窦(TS)狭窄。
评估在药物治疗期间IIH患者脑脊液压力恢复正常后TS狭窄是否发生改变。
对14例在药物治疗期间经脑磁共振静脉血管造影(MRV)显示为双侧TS狭窄的IIH患者进行连续研究。对患者进行了超过6年的随访。在随访期间,患者接受了多次腰椎穿刺(LP)和脑MRV检查。每次LP前均进行MRV检查。
随访期间所有患者的TS狭窄持续存在。14例IIH患者中有9例(64%)在药物治疗期间脑脊液压力恢复正常。
经MR静脉血管造影显示,特发性颅内高压患者脑脊液压力恢复正常后,TS狭窄仍然存在,提示TS管径与脑脊液压力之间缺乏直接关系。