柔脑膜转移患者脑脊液中血管生成相关蛋白的水平
CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases.
作者信息
Reijneveld J C, Brandsma D, Boogerd W, Bonfrer J G M, Kalmijn S, Voest E E, Geurts-Moespot A, Visser M C, Taphoorn M J B
机构信息
Department of Neurology, University Medical Center Utrecht, The Netherlands.
出版信息
Neurology. 2005 Oct 11;65(7):1120-2. doi: 10.1212/01.wnl.0000178981.39984.c2.
The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.
作者测定了柔脑膜转移（LM；n = 53）患者、无LM的癌症患者（n = 18）以及无恶性肿瘤的受试者（n = 25）脑脊液中血管内皮生长因子（VEGF）和尿激酶型纤溶酶原激活剂（uPA）的水平。LM患者中uPA和VEGF的中位数水平显著更高，支持血管生成促成LM的假说。VEGF与LM患者的生存率呈负相关，提示其可作为一个预后因素。
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