Valsasina P, Benedetti B, Rovaris M, Sormani M P, Comi G, Filippi M
Neuroimaging Research Unit, Scientific Institute and University H San Raffaele, Via Olgettina 60, 20132 Milan, Italy.
Neurology. 2005 Oct 11;65(7):1126-8. doi: 10.1212/01.wnl.0000178982.53965.70.
Little is known about the temporal evolution of gray matter damage occurring early in the course of multiple sclerosis (MS). The authors investigated the evolution of gray matter volume loss in 117 patients with relapsing-remitting MS, scanned monthly for a 9-month period. Time-trend analysis revealed a decrease of gray matter volumes over the study period (p < 0.001). This study shows that gray matter damage in relapsing-remitting MS evolves markedly over a short period of observation.
对于多发性硬化症（MS）病程早期发生的灰质损伤的时间演变知之甚少。作者对117例复发缓解型MS患者的灰质体积损失演变进行了研究，在9个月的时间里每月进行扫描。时间趋势分析显示，在研究期间灰质体积减少（p < 0.001）。这项研究表明，复发缓解型MS的灰质损伤在短时间观察内有明显演变。
