Hernández-Borges Javier, Rodríguez-Delgado Miguel Angel, García-Montelongo Francisco J, Cifuentes Alejandro
Department of Analytical Chemistry, Nutrition and Food Science, University of La Laguna, La Laguna, Tenerife, Spain.
Electrophoresis. 2005 Oct;26(20):3799-813. doi: 10.1002/elps.200500084.
Chiral separation of enantiomers is one of the most challenging tasks for any analytical technique including CE. Since the first report in 1985 showing the great possibilities of CE for the separation of chiral compounds, the amount of publications concerning this topic has quickly increased. Although chiral electromigration methods have mainly been used for enantioseparation of drugs and pharmaceuticals, they have also been applied to analyze chiral pollutants. This article intends to provide an updated overview, including works published till January 2005, on the principal applications of CE to the chiral analysis of pollutants and their metabolites, with special emphasis on articles published in the last 10 years. The main advantages and drawbacks regarding the use of CE for chiral separation of pollutants are addressed including some discussion on the foreseen trends of electromigration procedures applied to chiral analysis of contaminants.
对映体的手性分离是包括毛细管电泳（CE）在内的任何分析技术最具挑战性的任务之一。自1985年首次报道显示CE在分离手性化合物方面具有巨大潜力以来，有关该主题的出版物数量迅速增加。尽管手性电迁移方法主要用于药物和药品的对映体分离，但它们也已应用于分析手性污染物。本文旨在提供一个最新综述，涵盖截至2005年1月发表的关于CE在污染物及其代谢物手性分析中的主要应用的研究，特别强调过去10年发表的文章。文中讨论了使用CE对手性污染物进行分离的主要优点和缺点，还对应用于污染物手性分析的电迁移方法的未来趋势进行了一些探讨。
